Biosurfactants

Pseudomonas aeruginosa is a Gram-negative organism ubiquitously available in both soil and water is referred notoriously as opportunistic pathogen, because of its capability of causing diseases such as: infections, cancers, cystic fibrosis and acute pneumonia by taking the advantage of well equipped target disruption mechanisms (Favre-Bonté, 2007). It establishes infection by producing remarkable group of virulent products that may be cell associated or even extracellular. However, these virulent products are regulated by a complex and interlinked quorum sensing systems (genes), that seems to be responsible for other metabolisms at the same time. Besides, this kind of advanced communication helps the bacteria to proceed in a much organized regulatory patterns of gene expression, which is actually believed to give the bacteria a discerning advantage over the defense mechanisms of the host (Smith and Iglewski, 2003).

References:


Rahman, K.S.M., Rahman, T.J., McClean, S., Marchant, R., and Banat, I.M. (2002). Rhamnolipid biosurfactants production by strains of Pseudomonas aeruginosa using low cost raw materials. Biotechnol. Prog. 18, 277-281.

Rahman, K.S.M., Vasudevan, N., and Lakshmanaperumalsamy, P. (1999). Enhancement of biosurfactant production to emulsify different hydrocarbons, J. Environ. Poll. 6, 87-93.

Moran, A.C., Olivera, N., Commendatore, M., Esteves, J.L. and Sineriz, F. (2000). Enhancement of hydrocarbon waste biodegradation by addition of a biosurfactant from Bacillus subtilis O9. Biodegradation. 11, 65-71.

Maneerat. S., (2005). Production of biosurfactants using substrates from renewable-resources. J. Sci. Technol. 27, 675-683.

Mukherjee, S., Das, P., and Sen, R. (2006). Towards the commercial production of microbial surfactants. Trends Biotechnol. 24, 509-515.

Oliveira, F.J.S., Vazquez, L., de Campos, N.P., and de Franca, F.P. (2009). Production of rhamnolipids by a Pseudomonas alcaligenes strain. Process Biochem. 44, 383-389.

Favre-Bonté,S. (2007). Autoinducer production and quorum-sensing dependent phenotypes of Pseudomonas aeruginosa vary according to isolation site during colonization of intubated patients. BMC Microbiology 7(33), 1-12.

Smith, R. S., and Iglewski, B.H. (2003). Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target. J. Clin. Invest. 112,1460–1465.